人才队伍

王焱

教授/主任医师/博导

医生简介

学科（专业）:内科学（心血管）

研究方向：心血管疾病的临床与基础研究

邮箱【yóu xiāng】📏：wy@medmail.com.cn

电话：0592-2292320

教育背景：

1985-1990 西安医科大学【kē dà xué】🛂 临床医⛺学本科【běn kē】

1993-1996 新疆医科大学心血管【xīn xuè guǎn】🥙内科【nèi kē】🤽 硕士

1999-2004 香港大【xiāng gǎng dà】📚学医学院🤥 心血管内科博士【bó shì】

工作经历：

1990.07-1996.09 新疆医科大学附属第【fù shǔ dì】👟一医院【yī yī yuàn】👥 心内科【xīn nèi kē】主治医师🍊

1996.07-2001.07 香港玛丽医院心内科❄ 注册医【zhù cè yī】师【shī】😬

2002.07-2003.07 香港圣保禄医【bǎo lù yī】🏪院心内科【xīn nèi kē】注册医师🌰

2001.03-2014.12 厦门大学附属【xué fù shǔ】🐤中山医院🛵 心内科【xīn nèi kē】主任医【zhǔ rèn yī】师🎫

2015.01-2016.08 厦门市🔩心血管😲病医院【bìng yī yuàn】（厦门市🔩心🆙脏中心【zāng zhōng xīn】🆙）院长【yuàn zhǎng】

2016.09- 至【zhì】今漫蛙【màn wā】😴MANWA官网版-manwa漫蛙【màn wā】😴防走失【fáng zǒu shī】站-蛙👑manwa2下载-MANWA（厦门市🌦心📥脏中心📥）院长【yuàn zhǎng】

主要研究领域：

王焱教授长期🥀从事心血管转化医学研究【jiū】👳，主要兴【zhǔ yào xìng】趣在心🐉脏介入临床研【lín chuáng yán】🖇究【jiū】、动脉粥【dòng mò zhōu】样硬化【yàng yìng huà】👺机制与临床研【lín chuáng yán】🖇究【jiū】、缺血再🚐灌注损伤与心肌保护【jī bǎo hù】研究【jiū】👳、心脏干细胞移💇植治疗、离子通道与心🚃律失常发病机😳制研究【jiū】👳，中药对心血管疾病治【jí bìng zhì】🍜疗作用研究【jiū】等🧜；近年来🌲以第一【yǐ dì yī】🤗/通讯作【tōng xùn zuò】者在国际知名💪杂志发👣表论著20余篇【yú piān】；承担国家自然【jiā zì rán】科学基金重点项目【xiàng mù】、国家科【guó jiā kē】技部重点研发【diǎn yán fā】🐪项目【xiàng mù】等国家、省【shěng】、市级科研项目【xiàng mù】10余项【yú xiàng】🛍，科研经费超过【fèi chāo guò】🍘2000万元【wàn yuán】。

主要学【zhǔ yào xué】🌬术成果：

论文（*为通讯作者）：

1. . Xiang D, Xiang X, Zhang W, Yi S, Zhang J, Gu X, Xu Y, Huang K, Su X, Yu B, Wang Y, Fang W, Huo Y, Ge J. Management and Outcomes of Patients With STEMI During the COVID-19 Pandemic in China. J Am Coll Cardiol. 2020; 76: 1318-24.

2. Song F, Zhou XX, Hu Y, Li G*, Wang Y*. The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases. Adv Ther. 2020.

2. Wu Y, Song F, Li Y, Li J, Cui Y, Hong Y, Han W, Wu W, Lakhani I, Li G*, Wang Y*. Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE(-/-) Mice. J Cell Mol Med. 2020.

3. Fu R, Song C, Yang J, Gao C, Wang Y, Xu H, Gao X, Fan X, Xu H, Wang H, Dou K, Yang Y, Study CR. A Practical Risk Score to Predict 24-Month Post-Discharge Mortality Risk in Patients With Non-ST-Segment Elevation Myocardial Infarction. Circ J. 2020; 84: 1974-80.

4. Ni E, Fang Y, Ma F, Ge G, Wu J, Wang Y, Lin Y, Xie H. A one-step potentiometric immunoassay for plasma cardiac troponin I using an antibody-functionalized bis-MPA-COOH dendrimer as a competitor with improved sensitivity. Anal Methods. 2020; 12: 2914-21.

5. Wu WY, Cui YK, Hong YX, Li YD, Wu Y, Li G, Li GR, Wang Y*. Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules. J Cell Mol Med. 2020; 24: 12141-53.

6. Guo J, Li L, Xiao G, Huang X, Li Q, Wang Y, Cai B. Feasibility and stability of left bundle branch pacing in patients after prosthetic valve implantation. Clin Cardiol. 2020; 43: 1110-8.

7. Wang Y*, Xiao G, Zhang G, Wang B, Lin Z, Saiwha HD, You H, Lai K, Su M, Wen H, Wang J, Annest L, Tse G. Early Results of the Revivent TC Procedure for Treatment of Left Ventricular Aneurysm and Heart Failure due to Ischemic Cardiomyopathy. EuroIntervention. 2020.

8. Zhang K, Wu WY, Li G, Zhang YH, Sun Y, Qiu F, Yang Q, Xiao GS, Li GR, Wang Y*. Regulation of the TRPC1 channel by endothelin-1 in human atrial myocytes. Heart Rhythm. 2019; 16: 1575-83.

9. Zhang R, Jie LJ, Wu WY, Wang ZQ, Sun HY, Xiao GS, Wang Y, Li YG, Li GR. Comparative study of carvedilol and quinidine for inhibiting hKv4.3 channel stably expressed in HEK 293 cells. Eur J Pharmacol. 2019; 853: 74-83.

10. Chang H, Zhao F, Xie X, Liao Y, Song Y, Liu C, Wu Y, Wang Y, Liu D, Wang Y, Zou J, Qi Z. PPARalpha suppresses Th17 cell differentiation through IL-6/STAT3/RORgammat pathway in experimental autoimmune myocarditis. Exp Cell Res. 2019; 375: 22-30.

11. Li G, Che H, Wu WY, Jie LJ, Xiao GS, Wang Y*, Li GR*. Bradykinin-mediated Ca(2+) signalling regulates cell growth and mobility in human cardiac c-Kit(+) progenitor cells. J Cell Mol Med. 2018; 22: 4688-99.

12. Guo JC, Huang WB, Zhou FG, Hong J, Wang Y*. Sustained localized reentry within the left atrial appendage as a mechanism of recurrent arrhythmia following atrial fibrillation ablation. Exp Ther Med. 2018; 16: 772-8.

13. Li G, Song Y, Li YD, Jie LJ, Wu WY, Li JZ, Zhang Q, Wang Y*. Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure. Biomark Med. 2018; 12: 871-80.

14. Xiao GS, Zhang YH, Wang Y, Sun HY, Baumgarten CM, Li GR. Noradrenaline up-regulates volume-regulated chloride current by PKA-independent cAMP/exchange protein activated by cAMP pathway in human atrial myocytes. Br J Pharmacol. 2018; 175: 3422-32.

15. Wu WY, Li YD, Cui YK, Wu C, Hong YX, Li G, Wu Y, Jie LJ, Wang Y*, Li GR*. The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway. Front Pharmacol. 2018; 9: 497.

16. Chen KH, Liu H, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR*. The Natural Flavone Acacetin Blocks Small Conductance Ca(2+)-Activated K(+) Channels Stably Expressed in HEK 293 Cells. Front Pharmacol. 2017; 8: 716.

17. Deng XL, Wang Y, Xiao GS. Effects of equol on multiple K+ channels stably expressed in HEK 293 cells. PLoS One. 2017; 12: e0183708.

18. Wang Y, Sun HY, Liu YG, Song Z, She G, Xiao GS, Wang Y, Li GR, Deng XL. Tyrphostin AG556 increases the activity of large conductance Ca(2+) -activated K(+) channels by inhibiting epidermal growth factor receptor tyrosine kinase. J Cell Mol Med. 2017; 21: 1826-34.

19. Li G, Wang Y*, Li GR*. Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells. Oncotarget. 2017; 8: 10822-35.

20. Xiao GS, Zhang YH, Wu W, Sun HY, Wang Y, Li GR*. Genistein and tyrphostin AG556 decrease ultra-rapidly activating delayed rectifier K(+) current of human atria by inhibiting EGF receptor tyrosine kinase. Br J Pharmacol. 2017; 174: 454-67.

21. Jie LJ, Wu WY, Li G, Xiao GS, Zhang S, Li GR*, Wang Y*. Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells. Br J Pharmacol. 2017; 174: 254-66.

22. Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR*. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Sci Rep. 2016; 6: 36435.

23. Wang Y, Wang Y*, Li GR*. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. 2016; 7: 50937-51.

24. Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR*. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Sci Rep. 2016; 6: 25743.

25. Che H, Xiao GS, Sun HY, Wang Y*, Li GR*. Functional TRPV2 and TRPV4 channels in human cardiac c-kit(+) progenitor cells. J Cell Mol Med. 2016; 20: 1118-27.

26. Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR. SKF-96365 blocks human ether-a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Pharmacol Res. 2016; 104: 61-9.

27. Chen KH, Xu XH, Sun HY, Du XL, Liu H, Yang L, Xiao GS, Wang Y, Jin MW, Li GR. Distinctive property and pharmacology of voltage-gated sodium current in rat atrial vs ventricular myocytes. Heart Rhythm. 2016; 13: 762-70.

28. Che H, Li G, Sun HY, Xiao GS, Wang Y, Li GR*. Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-kit+ progenitor cells. Am J Physiol Heart Circ Physiol. 2015; 309: H1772-81.

29. Zhang YY, Li G, Che H, Sun HY, Xiao GS, Wang Y*, Li GR*. Effects of BKCa and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit+ Progenitor Cells. PLoS One. 2015; 10: e0138581.

30. Wang B, Wang Y*. Acute coronary syndrome caused by left main coronary artery compression between the aortic root and massive dilation of the left atrium. Can J Cardiol. 2015; 31: 227 e3-5.

31. Wang B, Wang Y, Ye T, Xiao G, Chang H, Wen H, Chen Y, Lin J, Yang L, Ye J, Huang L, Chen L, Cui Y, Fan C, Wu Y, Zheng Q. [Integrated regional network construction for ST-segment elevation myocardial infarction care]. Zhonghua Xin Xue Guan Bing Za Zhi. 2014; 42: 650-4.

32. Chang H, Wang Y, Wu W, Li G, Hanawa H, Zou J. Hydrodynamics-based delivery of an interleukin-1 receptor II fusion gene ameliorates rat autoimmune myocarditis by inhibiting IL-1 and Th17 cell polarization. Int J Mol Med. 2013; 31: 833-40.

33. Wang Y, Li G, Tang JX, Chang H. [Time course of interleukin-21 and related cytokines expression in rats with experimental autoimmune myocarditis]. Zhonghua Xin Xue Guan Bing Za Zhi. 2012; 40: 43-9.

34. Wang Y, Chang H, Zou J, Jin X, Qi Z. The effect of atorvastatin on mRNA levels of inflammatory genes expression in human peripheral blood lymphocytes by DNA microarray. Biomed Pharmacother. 2011; 65: 118-22.

科研项目（部分）：

1.国家自🤭然科学【rán kē xué】🧤基金海【jī jīn hǎi】峡联合基金项目，心脏祖细胞在心肌梗【xīn jī gěng】死修复👩中的机制研究，2017.01-2020.01，主持【zhǔ chí】⏺

2.科技部重点研🎟发项目【fā xiàng mù】，急性心【jí xìng xīn】肌梗死【jī gěng sǐ】🧢全程心肌保护体系研😭究，2016.09-2020.12

3.厦门市科技局🐽重大科技平台项目，冠心病🌂急症的【jí zhèng de】远程诊【yuǎn chéng zhěn】断和区【duàn hé qū】域协同♑救治平【jiù zhì píng】🥖台二期，2015.10-2018.09，主持

4.厦门市重大疾🧡病联合🎢公关项【gōng guān xiàng】🛥目，经导管主动脉【zhǔ dòng mò】瓣植入【bàn zhí rù】在高危重度主动脉【zhǔ dòng mò】瓣狭窄合🎠并左室功能不全患者中的临🛥床应用🧜研究【yán jiū】，2015.01-2017.12，主持【zhǔ chí】

5.福建省科技厅重点项目💡，经皮导🥡管肾脏【guǎn shèn zāng】🥀去神经🙂法治疗【fǎ zhì liáo】顽固性【wán gù xìng】高血压的临床【de lín chuáng】技术研🐫究【jiū】2014.01-2017.01，主持

6.国家自然基金面上项目😿，Kv1.3 通道在🔨动脉粥【dòng mò zhōu】样硬化中的作【zhōng de zuò】用研究，2009.01-2011.12，主持【zhǔ chí】🔯

获奖：

1.2016年福建✌省科学技术奖一等奖，急性冠脉综合🕙征区域【zhēng qū yù】协同救【xié tóng jiù】🔔治体系的创新【de chuàng xīn】🏑及应用【jí yīng yòng】示范

2.2015年厦门市重大【shì chóng dà】🎯贡献奖，全市覆盖区域🐐协同胸【xié tóng xiōng】痛急救【tòng jí jiù】网络🦌

3.2014年厦门市科学⛵技术奖三等奖🐗，CD4+T淋巴细胞【bāo】Kv1.3通道在大鼠动【dà shǔ dòng】脉粥样🛹硬化中【yìng huà zhōng】🌽的作用【de zuò yòng】研究

4.2014年中国医师奖（第九届）

5.2016年厦门市医学【shì yī xué】创新奖【chuàng xīn jiǎng】，经导管📆主动脉瓣植入术的临👣床应用【chuáng yīng yòng】📥及推广

6.2015年厦门市医学创新奖😆，区域协【qū yù xié】同【tóng】ST段抬高🗨型心肌梗死救💱治网络建设及临床应【lín chuáng yīng】🔜用【yòng】

7.2014年厦门市医学📌创新奖，冠脉内【guàn mò nèi】📚压力导丝技术在冠脉【zài guàn mò】🆒造影临【zào yǐng lín】界病变中的应【zhōng de yīng】用📫